Serena and Venus Williams withdrew from the hard court tournament in Cincinnati on Tuesday, becoming the latest high-profile players to exit the US Open.
Joining the Williams Sisters, and American Sofia Cannon, Roger Federer and Novak Djokovic as stars who will miss the ATP and WTA tournaments in Ohio.
Serena, a two-time Cincinnati winner, said the leg injury she suffered at Wimbledon last month is still bothering her.
“Unfortunately, I will not play in the Western and Southern Open next week as I am currently recovering from a leg injury at Wimbledon,” he said in a statement.
“I will miss all my fans in Cincinnati that I look forward to seeing every summer. I plan to be back on the court soon.”
The reason for Venice’s withdrawal was not disclosed, but Cannon said she was recovering from a foot injury in hopes of playing in the US Open later this month.
“I think another week of recovery is needed,” Cannon said.
Seven-time Cincinnati champion Swiss great Federer said last week that he would be ruled out of the tournament due to a knee injury that ruled him out of the Tokyo Olympics.
Djokovic announced on social media on Monday that he would leave Cincinnati, saying he needed more time to recover after the Tokyo Games.