Tottenham are looking to boost confidence in the Europa Conference League after a worrying drop to host Slovenians Mora on Thursday, while their former manager Jose Mourinho took his free-scoring Roma to Zoria Luhansk.
The Spurs began the Premier League season with a three-straight 1-0 win under Nono Esprito Santo, but have since suffered three consecutive defeats, scoring nine goals in the process.
His defeats to rivals Crystal Palace, Chelsea and Arsenal in London have raised questions about new manager Nono.
The Hurricanes have yet to score in five league games as they have failed to move to Manchester City in the upcoming season.
“The performance was not good. The game plan was not good. The decisions were not good,” former Wales boss Nono admitted to Arsenal after a 3-1 derby defeat on Sunday.
The Spurs also need points in the opening conference league after opening the group stage with a 2-2 draw at the Rains.
Anything other than the victory over Mora, which ranks fifth in Slovenia’s top flight, will see Nono and his team under further scrutiny before playing against Austin Villa this weekend.
Spurs, without a trophy since 2008, parted ways with Mourinho shortly before losing to Manchester City in last season’s League Cup final.
But the Portuguese have enjoyed a strong start with Roma, despite losing 3-2 to Lazio in a derby clash last week.
Spurs fans have often criticized the negative nature of his game, with Moreno having seen his Roma team score 24 goals in just nine matches during this period.
He will seek his own response against Luhansk, even after railing against the referee’s decisions in Lazio’s loss.
“The referee and VAR did not meet the standard of the match at this level,” he said.
Coach Moreno, a two-time Champions League winner, now finds himself handling very few glamorous third-tier conference leagues.
But Roma last sent a statement of intent to Europe as a strong side beat CSKA Sofia 5-1.
Scottish giants Celtic have endured a tough campaign so far, despite some shine in homes under the Ang Posticoglu.
He greets Byron Leverkusen at Parkhead after losing 4-3 to Real Betis in the Europa League group stage opener.
A strong start to the season at home has given respite, but Dundee United held the Celtics to the Glasgow weekend six points behind the Scottish Premiership champions Rangers.
A win over Bundesliga side Leverkusen will leave Hopes with some sadness, when he was promoted by his own fans on Sunday.
Steven Gerrard’s Rangers need a positive result in Sparta Prague to boost their hopes of reaching the knockout stage for the third consecutive season after losing to Lyon.
Lyon plays Brundby in the second Group A match at Groupama Stadium.
Elsewhere on the farm, West Ham hosts Rapid Vienna and Leicester visit Legia Warsaw.